FluidFM: Precise fluidic positioning and delivery platform with applications in cell biology and soft matter

Microscopy & Analysis, June 2018

Patrick Frederix, Paul Werten, Dalia Yablon

The platform of fluid force microscopy (FluidFM) offers researchers unique capabilities in precise and well-controlled fluid delivery in small quantities down to femtoliters to the surface. It is based on a microfluidic controller coupled with an innovative AFM probe where a microchannel is hollowed out so that the probe essentially functions as a nanopipette. Applications of FluidFM are described including enhanced manipulation of cells, improved force measurements on biological materials including bacteria, and fluidic writing on hydrogels.